Pacific Northwest Research Station

Title: Lanostane-type triterpenes from the mushroom Astraeus pteridis with Antituberculosis Activity

Author: Stanikunaite, Rita; Radwan, Mohamed; Trappe, James M.; Fronczek, Frank; Ross, Samir A.

Date: 2008

Source: Journal of Natural Products. 71: 2077-2079

Description: Bioassay-guided fractionation of an EtOH extract of the truffle-mimiking mushroom Astraeus pteridis led to the isolation and identification of three new (3-5) and two known (1, 2) lanostane triterpenes and phenylalanine betaine (6). The structures of the isolates were elucidated on the basis of 1D and 2D NMR spectroscopic data, HRESIMS results, and X-ray crystallographic analysis. Compounds 5 and 1 showed moderate activity against Mycobacterium tuberculosis with MIC values of 34.0 and 58.0 μg/mL, respectively.

Keywords: Mushroom, Astraeus pteridis, lanostane triterpenes

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Citation

Stanikunaite, Rita; Radwan, Mohamed; Trappe, James M.; Fronczek, Frank; Ross, Samir A.  2008.  Lanostane-type triterpenes from the mushroom Astraeus pteridis with Antituberculosis Activity.   Journal of Natural Products. 71: 2077-2079.