Skip to page content
USDA Forest Service

Research & Development Treesearch

Treesearch Home
About Treesearch
Contact Us
Research & Development
Forest Products Lab
International Institute of Tropical Forestry
Pacific Northwest
Pacific Southwest
Rocky Mountain
Southern Research Station
Help - We Participate  Government Made Easy

Global Forest Information Service

US Forest Service
P.O. Box 96090
Washington, D.C.

(202) 205-8333

You are here: Home / Search / Publication Information
Bookmark and Share

Publication Information

View PDF (101 KB bytes)

Title: Interactions of flavanoids with bradykinin in aqueous solution

Author: Berke, B.; Tobiason, F.L.; Hatano, T.; Cheze, C; Vercauteren, J.; Hemingway, Richard W.;

Date: 1999

Source: Polyphenols, wine and health communications; polyphenols, wine and health symposium; 1999 April 14-16; Bordeaux, France.

Publication Series: Miscellaneous Publication

Description: Complexation with proteins is central to much of the biological and industrial significance of plant polyphenols. Definition of the interaction of these two classes of biopolymers has, therefore, been studied for decades. The most important mechanism seems to involve hydrophobic interactions and also hydrogen bonding, but to a smaller extent. Study of specific interactions between polyphenols and peptides has been pursued using Nuclear Magnetic Resonance (NMR). Hatano showed that information required for conformation and complexation determination can be obtained from nuclear Overhauser effect spectroscopy. NMR experiments can be guided by Macromodel molecular modeling by applying Monte Carlo methods to the conformational searching on complexes. Results show that the interaction is directed to conformationally accessible hydrophobic regions and emphasize the importance of the shape of both the flavanoid and the peptide.

Epidemiological findings have shown that incidence of cardiovascular and neurologic degenerative diseases appears to be lower for populations with regular but moderate drinking of red wine that contains flavanoids such as catechin and procyanidins. To understand the effects of flavanoids on human health, it is important to obtain an accurate assessment of their interactions with polypeptides involved in the control of blood pressure and cardiovascular functions such as bradykinin.. Furthermore, the multiple structural features of bradykinin provide avenues to explore conformational selectivity. In addition to two proline and phenylalanine residues, two arginine residues are present at each end of the peptide, hence the authors’ interest in this system.

Publication Notes:

  • We recommend that you also print this page and attach it to the printout of the article, to retain the full citation information.
  • This article was written and prepared by U.S. Government employees on official time, and is therefore in the public domain.
  • You may send email to to request a hard copy of this publication. (Please specify exactly which publication you are requesting and your mailing address.)



Berke, B.; Tobiason, F.L.; Hatano, T.; Cheze, C,; Vercauteren, J.; Hemingway, Richard W. 1999. Interactions of flavanoids with bradykinin in aqueous solution. Polyphenols, wine and health communications; polyphenols, wine and health symposium; 1999 April 14-16; Bordeaux, France.


 [ Get Acrobat ]  Get the latest version of the Adobe Acrobat reader or Acrobat Reader for Windows with Search and Accessibility

USDA logo which links to the department's national site. Forest Service logo which links to the agency's national site.