Skip to page content
USDA Forest Service

Research & Development Treesearch

Treesearch Home
About Treesearch
Contact Us
Research & Development
Forest Products Lab
International Institute of Tropical Forestry
Pacific Northwest
Pacific Southwest
Rocky Mountain
Southern Research Station
Help - We Participate  Government Made Easy

Global Forest Information Service

US Forest Service
P.O. Box 96090
Washington, D.C.

(202) 205-8333

You are here: Home / Search / Publication Information
Bookmark and Share

Publication Information

View PDF (211 KB)

Title: Yeast metabolic engineering for hemicellulosic ethanol production

Author: Van Vleet, Jennifer; Jeffries, Thomas W.;

Date: 2009

Source: Current opinion in biotechnology. Vol. 20, no. 3 (June 2009): pages 300-306.

Publication Series: Miscellaneous Publication

Description: Efficient fermentation of hemicellulosic sugars is critical for the bioconversion of lignocellulosics to ethanol. Efficient sugar uptake through the heterologous expression of yeast and fungal xylose/glucose transporters can improve fermentation if other metabolic steps are not rate limiting. Rectification of cofactor imbalances through heterologous expression of fungal xylose isomerase or modification of cofactor requirements in the yeast oxidoreductase pathway can reduce xylitol production while increasing ethanol yields, but these changes often occur at the expense of xylose utilization rates. Genetic engineering and evolutionary adaptation to increase glycolytic flux coupled with transcriptomic and proteomic studies have identified targets for further modification, as have genomic and metabolic engineering studies in native xylose fermenting yeasts

Keywords: Alcohol, yeast fungi, biotechnology, fungi, industrial applications, genetic engineering, microbial metabolism, genetics, lignocellulose, fermentation, gene expression, genomes, wood-decaying fungi, genetic transcription, Saccharomyces cerevisiae, hemicellulose, sugars, glucose, oxidoreductase, ethanol, decay fungi, xylose, bioconversion

Publication Notes:

  • We recommend that you also print this page and attach it to the printout of the article, to retain the full citation information.
  • This article was written and prepared by U.S. Government employees on official time, and is therefore in the public domain.



Van Vleet, Jennifer; Jeffries, Thomas W. 2009. Yeast metabolic engineering for hemicellulosic ethanol production. Current opinion in biotechnology. Vol. 20, no. 3 (June 2009): pages 300-306.


 [ Get Acrobat ]  Get the latest version of the Adobe Acrobat reader or Acrobat Reader for Windows with Search and Accessibility

USDA logo which links to the department's national site. Forest Service logo which links to the agency's national site.