Skip to page content
USDA Forest Service

Research & Development Treesearch

Treesearch Home
About Treesearch
Contact Us
Research & Development
Forest Products Lab
International Institute of Tropical Forestry
Pacific Northwest
Pacific Southwest
Rocky Mountain
Southern Research Station
Help - We Participate  Government Made Easy

Global Forest Information Service

US Forest Service
P.O. Box 96090
Washington, D.C.

(202) 205-8333

You are here: Home / Search / Publication Information
Bookmark and Share

Publication Information

View PDF (656 KB)

Title: Wood hemicellulose/chitosan-based semi-interpenetrating network hydrogels : mechanical swelling and controlled drug release properties

Author: Karaaslan, Ahmet M.; Tshabalala, Mandla A.; Buschle-Diller, Gisela;

Date: 2010

Source: Bioresources. Vol. 5, no. 2 (2010): p. 1036-1054.

Publication Series: Miscellaneous Publication

Description: The cell wall of most plant biomass from forest and agricultural resources consists of three major polymers, cellulose, hemicellulose, and lignin. Of these, hemicelluloses have gained increasing attention as sustainable raw materials. In this study, novel pH-sensitive semi-IPN hydrogels based on hemicelluloses and chitosan were prepared using glutaraldehyde as the crosslinking agent. The hemicellulose isolated from aspen was analyzed for sugar content by HPLC, and its molecular weight distribution was determined by high performance size exclusion chromatography. Results revealed that hemicellulose had a broad molecular weight distribution with a fair amount of polymeric units, together with xylose, arabinose, and glucose. The effects of hemicellulose content on mechanical properties and swelling behavior of hydrogels were investigated. The semi-IPNs hydrogel structure was confirmed by FT-IR, X-ray study, and the ninhydrin assay method. X-ray analysis showed that higher hemicellulose contents yielded higher crystallinity. Mechanical properties were mainly dependent on the crosslink density and average molecular weight between crosslinks. Swelling ratios increased with increasing hemicellulose content and were high at low pH values due to repulsion between similarly charged groups. In vitro release study of a model drug showed that these semi-IPN hydrogels could be used for controlled drug delivery into gastric fluid.

Keywords: Colloids, hemicellulose, aspen, chitosan, crosslinking, sugars, high performance liquid chromatography, glucose, fourier transform infrared spectroscopy, mechanical properties, vitamin B2, drug delivery systems, crystallization, hydrogels, biorefining, glutaraldehyde, HPLC, xylose, arabinose, swelling

Publication Notes:

  • We recommend that you also print this page and attach it to the printout of the article, to retain the full citation information.
  • This article was written and prepared by U.S. Government employees on official time, and is therefore in the public domain.



Karaaslan, Ahmet M.; Tshabalala, Mandla A.; Buschle-Diller, Gisela. 2010. Wood hemicellulose/chitosan-based semi-interpenetrating network hydrogels: mechanical swelling and controlled drug release properties. Bioresources. 5(2): 1036-1054.


 [ Get Acrobat ]  Get the latest version of the Adobe Acrobat reader or Acrobat Reader for Windows with Search and Accessibility

USDA logo which links to the department's national site. Forest Service logo which links to the agency's national site.